Endocrine Abstracts

Introduction: Sclerostin is well-known as an inhibitor of bone formation but also promotes bone resorption. Acromegaly is a disease characterized by increased bone turnover and higher vertebral fracture risk.Purpose: The aim of the study was to determine sclerostin levels in acromegaly patients with regard to the disease activity. We also evaluated the associations between sclerostin and random growth hormone (GH), insulin-like growth factor 1 (IGF-I), l...

Background: Acromegaly is a rare disease, mostly caused by a GH (growth hormone)-secreting pituitary adenoma. The pathomechanism of bone complications remains not fully explored. The fibroblast growth factor-23 (FGF-23)/Klotho axis regulates phosphate and vitamin D metabolism.Objectives: The study aimed primarily at evaluating FGF-23 and Klotho concentrations with regard to acromegaly activity. The secondary goal was to identify associations between FGF-...

Acromegaly is characterized by two-fold higher mortality than in the general population. The leading causes of morbidity and mortality in patients with acromegaly are cardiovascular diseases (CVD). Many population-based studies suggest a role of genetic background in CVD and associated metabolic disturbances. In 2007, FTO (fat mass and obesity associated) gene polymorphisms were discovered. According to a few studies, the polymorphisms of FTO gene are associated with ...

Objectives: The excessive production of pro-inflammatory cytokines has been previously reported in the severe form of COVID-19. The cytokine storm is responsible for the induction of an inflammatory endothelial cell phenotype which is associated with the shedding of adhesion molecules. VCAM-1 is an endothelial adhesion protein that belongs to the immunoglobulin superfamily. Pro-inflammatory cytokines lead to the induction of VCAM-1 in the endothelium of blood vessels which is ...

Acromegaly is a rare disease, caused by an excessive secretion of growth hormone (GH), and consequently the insulin like growth factor 1 (IGF-1). Patients with acromegaly have an increased risk of fractures, which might be correlated with insufficient quality of bone. It is known that use of FRAX in acromegaly is not validated, however we do not have other useful tools to assess real risk for fractures. The new valuable tool in the assessment of bone structure is the trabecula...